Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727903 | 0.93 | MAPT (0.39) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL4730991 | 0.93 | APOBEC3A (0.33) | KDM4ENPC1RAB9ATP53 | |
| SCHEMBL4731374 | 0.90 | NTRK1 (0.34) | KDM4EMAPTNPSR1IKBKBPOLB | |
| SCHEMBL4731338 | 0.86 | IRAK4 (0.35) | MAPT | |
| SCHEMBL4728477 | 0.86 | SLC6A9 (0.35) | RXFP1TP53 | |
| SCHEMBL14223294 | 0.86 | NPC1 (0.37) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL14223017 | 0.85 | KDM4E (0.33) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL4732282 | 0.85 | KDM4E (0.32) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL4732771 | 0.85 | APOBEC3A (0.34) | KDM4ENPC1RAB9ATP53 | |
| SCHEMBL4731297 | 0.85 | TP53 (0.34) | KDM4EMAPTNPSR1IKBKBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |