Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671727 | 1.00 | MMP2 (0.41) | MMP2MMP3LMNATHRBSIGMAR1 | |
| SCHEMBL7461267 | 0.85 | MMP2 (0.39) | MMP2MMP3LMNATHRBSIGMAR1 | |
| SCHEMBL4676634 | 0.81 | LMNA (0.43) | MMP2MMP3LMNATHRBKDM4E | |
| SCHEMBL4673925 | 0.81 | LMNA (0.43) | MMP2MMP3LMNATHRBSIGMAR1 | |
| SCHEMBL4671560 | 0.81 | LMNA (0.43) | MMP2MMP3LMNATHRBKDM4E | |
| SCHEMBL4674820 | 0.81 | LMNA (0.43) | MMP2MMP3LMNATHRBSIGMAR1 | |
| SCHEMBL7447815 | 0.81 | LMNA (0.43) | MMP2MMP3LMNATHRBKDM4E | |
| SCHEMBL4674941 | 0.81 | MMP1 (0.48) | MMP2MMP3LMNATHRBSIGMAR1 | |
| SCHEMBL4673740 | 0.80 | USP5 (0.42) | MMP3MAPT | |
| SCHEMBL8149255 | 0.80 | MMP1 (0.47) | MMP2MMP3LMNATHRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |