Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 6/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733822 | 0.92 | SFRP1 (0.50) | MEN1KMT2AHTTPKMTDP1 | |
| SCHEMBL4733942 | 0.89 | POLB (0.48) | HTTTDP1ALDH1A1SMN1; SMN2SFRP1 | |
| SCHEMBL4729813 | 0.85 | SFRP1 (0.50) | MEN1KMT2AHTTPKMTDP1 | |
| SCHEMBL4733520 | 0.85 | MEN1 (0.48) | MEN1KMT2A | |
| SCHEMBL4734599 | 0.83 | POLB (0.48) | MEN1KMT2AHTTPKMMAPK1 | |
| SCHEMBL4732336 | 0.82 | AKR1C3 (0.41) | PKMTDP1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4733929 | 0.81 | PARG (0.39) | MEN1KMT2AHTTTDP1LMNA | |
| SCHEMBL4734109 | 0.78 | MEN1 (0.43) | MEN1KMT2AHTTPKMMAPK1 | |
| SCHEMBL4734759 | 0.78 | MEN1 (0.45) | MEN1KMT2AHTTPKMMAPK1 | |
| SCHEMBL4730493 | 0.77 | ALDH1A1 (0.40) | MEN1KMT2AHTTPKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |