Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733822 | 0.84 | SFRP1 (0.50) | TDP1SFRP1KMT2AMEN1HTT | |
| SCHEMBL4732336 | 0.81 | AKR1C3 (0.41) | PDE4BPDE4CPDE4DTDP1LMNA | |
| SCHEMBL4732136 | 0.81 | MEN1 (0.47) | TDP1LMNASFRP1KMT2AMEN1 | |
| SCHEMBL4733373 | 0.79 | BRD4 (0.40) | TDP1LMNACYP2C9KMT2AMEN1 | |
| SCHEMBL4729711 | 0.79 | ALDH1A1 (0.52) | CYP2C9KMT2AMEN1 | |
| SCHEMBL4733942 | 0.78 | POLB (0.48) | TDP1SFRP1HTTPOLB | |
| SCHEMBL4785987 | 0.78 | PARG (0.38) | PARGPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4731794 | 0.77 | CYP3A4 (0.49) | TDP1KMT2APOLB | |
| SCHEMBL4734831 | 0.77 | PARG (0.36) | PARGPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4733897 | 0.76 | CNR2 (0.40) | TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |