Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732136 | 0.92 | MEN1 (0.47) | SFRP1ALDH1A1HTTNPSR1L3MBTL1 | |
| SCHEMBL4729813 | 0.91 | SFRP1 (0.50) | SFRP1ALDH1A1HTTNPSR1L3MBTL1 | |
| SCHEMBL4733942 | 0.89 | POLB (0.48) | SFRP1ALDH1A1HTTNPSR1L3MBTL1 | |
| SCHEMBL4733929 | 0.84 | PARG (0.39) | SFRP1HTTTDP1POLBMEN1 | |
| SCHEMBL4734599 | 0.81 | POLB (0.48) | SFRP1ALDH1A1HTTNPSR1POLB | |
| SCHEMBL4729711 | 0.80 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1SMN1; SMN2PKMMEN1 | |
| SCHEMBL4733373 | 0.80 | BRD4 (0.40) | ALDH1A1L3MBTL1TDP1BRD4PKM | |
| SCHEMBL4731794 | 0.78 | CYP3A4 (0.49) | ALDH1A1L3MBTL1TDP1POLBPKM | |
| SCHEMBL4733897 | 0.77 | CNR2 (0.40) | HTTPKMNSD2 | |
| SCHEMBL4732619 | 0.77 | TAAR1 (0.43) | SFRP1ALDH1A1HTTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |