Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733982 | 0.88 | HTR2A (0.35) | CHEK1DAPK3MAP4K4RETPIM1 | |
| SCHEMBL4730132 | 0.79 | CYP17A1 (0.39) | MAOACA1CA2HTR2AHTR6 | |
| SCHEMBL4733537 | 0.76 | GPR3 (0.40) | MAOAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11823803 | 0.74 | AKR1C3 (0.40) | MAOAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24727227 | 0.72 | METAP1 (0.47) | METAP1CA1CA2HTR2ACA4 | |
| SCHEMBL11825540 | 0.71 | PTGS2 (0.44) | MAOA | |
| SCHEMBL4730720 | 0.70 | HCAR2 (0.33) | CHEK1DAPK3MAP4K4RETPIM1 | |
| SCHEMBL24727259 | 0.69 | METAP1 (0.44) | METAP1CA1CA2HTR2ACA4 | |
| SCHEMBL4734556 | 0.69 | KCNK2 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13932523 | 0.68 | MAOA (0.44) | MAOAMETAP1CA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |