Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 3/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | GALR1 | P47211 | 2/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | PPM1A | P35813 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733543 | 0.84 | GPR3 (0.40) | GPR3CES1CTSLTRPV4BACE1 | |
| SCHEMBL4732228 | 0.76 | MAOA (0.37) | MAOAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4730918 | 0.74 | GPR3 (0.39) | GPR3CES1GALR1SLC40A1CTSL | |
| SCHEMBL4730132 | 0.73 | CYP17A1 (0.39) | MAOA | |
| Ammonia Solution, Strong SCHEMBL2438706 | 0.70 | GPR3 (0.46) | GPR3CES1BACE1KIF11TRPV1 | |
| SCHEMBL4733115 | 0.69 | GPR3 (0.42) | GPR3CES1CTSLTRPV4BACE1 | |
| SCHEMBL11823803 | 0.68 | AKR1C3 (0.40) | MAOAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4733982 | 0.64 | HTR2A (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13932523 | 0.63 | MAOA (0.44) | MAOA | |
| SCHEMBL4730920 | 0.63 | GPR3 (0.39) | GPR3TRPV4PPM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |