Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732472 | 0.90 | ALDH1A1 (0.47) | ALDH1A1PKMKDM4EDPP4DPP8 | |
| SCHEMBL4731711 | 0.90 | ALDH1A1 (0.47) | ALDH1A1PKMKDM4EDPP4DPP8 | |
| SCHEMBL4729603 | 0.89 | SCD (0.51) | ALDH1A1PKMKDM4EDPP4DPP8 | |
| SCHEMBL4730640 | 0.88 | ALDH1A1 (0.44) | ALDH1A1PKMKDM4EDPP4DPP8 | |
| SCHEMBL4731167 | 0.86 | KDM4E (0.46) | ALDH1A1PKMKDM4EDPP4DPP8 | |
| SCHEMBL5090496 | 0.83 | MALT1 (0.45) | ALDH1A1PKMKDM4ESCDSLC6A7 | |
| SCHEMBL4731925 | 0.82 | CNR1 (0.49) | ALDH1A1PKMKDM4ESCDSLC6A7 | |
| SCHEMBL4733745 | 0.81 | KDM4E (0.48) | ALDH1A1PKMKDM4EDPP4DPP8 | |
| SCHEMBL4732131 | 0.81 | ALDH1A1 (0.46) | ALDH1A1PKMKDM4EDPP4DPP8 | |
| SCHEMBL5102741 | 0.80 | SLC6A7 (0.51) | ALDH1A1PKMKDM4ESLC6A7TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139598-A1 | Amine-linked Multicyclic Compounds and Methods of Their Use | LEXICON PHARMACEUTICALS, INC. | 2008-06-12 | — | — | US | claimed |
| WO-2008058064-A1 | AMINE-LINKED MULTICYCLIC COMPOUNDS AS INHIBITORS OF THE PROLINE TRANSPORTER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-05-15 | — | — | WO | claimed |
| US-20080139598-A1 | Amine-linked Multicyclic Compounds and Methods of Their Use | LEXICON PHARMACEUTICALS, INC. | 2008-06-12 | — | — | US | disclosed |
| WO-2008058064-A1 | AMINE-LINKED MULTICYCLIC COMPOUNDS AS INHIBITORS OF THE PROLINE TRANSPORTER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139598-A1 | Amine-linked Multicyclic Compounds and Methods of Their Use | MAOB, HNMT, MAOA | ALDH1A1 287/4885PKM 1033/4885KDM4E 2225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.