Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13962176 | 0.88 | ALDH1A1 (0.68) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19079736 | 0.81 | PDE4D (0.68) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19079693 | 0.81 | PDE4D (0.57) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19079823 | 0.81 | CREBBP (0.78) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19079754 | 0.79 | PDE4D (0.71) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19079750 | 0.78 | ALDH1A1 (0.73) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20228784 | 0.75 | KMT2A (0.85) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19079825 | 0.70 | CREBBP (0.63) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19079844 | 0.69 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL22533334 | 0.69 | SMN1; SMN2 (0.71) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275586-A1 | HETEROCYCLIC INHIBITORS OF PDE4 | KALYPSYS, INC. (US) | 2009-11-05 | — | — | US | disclosed |
| US-20090275586-A1 | HETEROCYCLIC INHIBITORS OF PDE4 | KALYPSYS, INC. (US) | 2009-11-05 | — | — | US | disclosed |
| WO-2008045664-A2 | HETEROCYCLIC PDE4 INHIBITORS AS ANTIINFLAMMATORY AGENTS | KALYPSYS, INC. (US) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275586-A1 | HETEROCYCLIC INHIBITORS OF PDE4 | PDE4A, PDE4B, PDE4C | ALDH1A1 779/4885NPSR1 3204/4885SMN1; SMN2 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.