Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | SFRP1 | Q8N474 | 7/20 | 0.57 |
| ▸ | STS | P08842 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CCR8 | P51685 | 1/20 | 0.52 |
| ▸ | WNT3 | P56703 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | MMP3 | P08254 | 3/20 | 0.48 |
| ▸ | MMP7 | P09237 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734056 | 0.89 | SFRP1 (0.48) | EPHX2SFRP1WNT3 | |
| SCHEMBL4856222 | 0.89 | SFRP1 (0.61) | EPHX2SFRP1STSCCR8WNT3 | |
| SCHEMBL4883255 | 0.88 | SFRP1 (0.59) | EPHX2SFRP1STSCCR8WNT3 | |
| SCHEMBL4735664 | 0.87 | SFRP1 (0.58) | EPHX2SFRP1STSCCR8WNT3 | |
| SCHEMBL4876888 | 0.85 | SFRP1 (0.56) | SFRP1STSCCR8WNT3BRD4 | |
| SCHEMBL6103230 | 0.85 | SFRP1 (0.76) | SFRP1WNT3 | |
| SCHEMBL4799560 | 0.84 | SFRP1 (0.62) | SFRP1CCR8WNT3BRD4 | |
| SCHEMBL4734835 | 0.84 | SFRP1 (0.56) | EPHX2SFRP1STSCCR8WNT3 | |
| SCHEMBL4736604 | 0.84 | SFRP1 (0.67) | SFRP1STSCCR8WNT3BRD4 | |
| SCHEMBL4846943 | 0.84 | SFRP1 (0.56) | EPHX2SFRP1STSCCR8WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |