Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 8/20 | 0.58 |
| ▸ | CCR8 | P51685 | 1/20 | 0.52 |
| ▸ | WNT3 | P56703 | 4/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | FPR3 | P25089 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4883255 | 0.89 | SFRP1 (0.59) | SFRP1CCR8WNT3BRD4STS | |
| SCHEMBL4732786 | 0.87 | EPHX2 (0.60) | SFRP1CCR8WNT3BRD4STS | |
| SCHEMBL4734111 | 0.86 | SFRP1 (0.51) | SFRP1WNT3 | |
| SCHEMBL4735919 | 0.86 | MCHR1 (0.51) | SFRP1CCR8WNT3BRD4STS | |
| SCHEMBL4876888 | 0.86 | SFRP1 (0.56) | SFRP1CCR8WNT3BRD4STS | |
| SCHEMBL4781511 | 0.85 | SFRP1 (0.46) | SFRP1WNT3KDM4EHSD17B10 | |
| SCHEMBL4799560 | 0.85 | SFRP1 (0.62) | SFRP1CCR8WNT3BRD4USP30 | |
| SCHEMBL4734835 | 0.85 | SFRP1 (0.56) | SFRP1CCR8WNT3BRD4STS | |
| SCHEMBL4736604 | 0.85 | SFRP1 (0.67) | SFRP1CCR8WNT3BRD4STS | |
| SCHEMBL4781516 | 0.84 | SFRP1 (0.51) | SFRP1WNT3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |