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SCHEMBL4733299

SCHEMBL4733299

COc1ccc(S(=O)(=O)NC2CCN(C(=O)c3ccc(Cl)nc3)CC2)c(C(F)(F)F)c1

nearest known ligand 0.64

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 14/20 0.64
▸ EPHX2 P34913 1/20 0.51
▸ NOS1 P29475 2/20 0.46
▸ NOS2 P35228 2/20 0.46
▸ NOS3 P29474 1/20 0.45
▸ PROKR1 Q8TCW9 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4738150 0.89 SFRP1 (0.69) SFRP1EPHX2
SCHEMBL4731611 0.89 SFRP1 (0.69) SFRP1EPHX2
SCHEMBL4737077 0.88 SFRP1 (0.68) SFRP1EPHX2
SCHEMBL4735165 0.87 SFRP1 (0.67) SFRP1EPHX2
SCHEMBL4734320 0.86 SFRP1 (0.64) SFRP1EPHX2
SCHEMBL4734362 0.86 SFRP1 (0.64) SFRP1EPHX2
SCHEMBL4732405 0.85 SFRP1 (0.77) SFRP1EPHX2
SCHEMBL4732049 0.85 SFRP1 (0.64) SFRP1EPHX2
SCHEMBL4733575 0.85 SFRP1 (0.71) SFRP1EPHX2
SCHEMBL4733163 0.85 SFRP1 (0.58) SFRP1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO claimed
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO disclosed