Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 5/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399833 | 0.83 | ALDH1A1 (0.49) | LMNAALDH1A1HPGDALOX15ATG4B | |
| SCHEMBL12446505 | 0.81 | ALDH1A1 (0.53) | LMNAALDH1A1HPGDALOX15ATG4B | |
| SCHEMBL8044706 | 0.75 | MAPK8 (0.63) | LMNAALDH1A1HPGDALOX15ATG4B | |
| SCHEMBL16208277 | 0.74 | LMNA (0.61) | LMNAALDH1A1ATG4BMAPK8MAPK9 | |
| SCHEMBL5888997 | 0.72 | CCNE1 (0.43) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2820592 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3262231 | 0.72 | KDR (0.51) | LMNAALDH1A1HPGDALOX15ATG4B | |
| SCHEMBL3262230 | 0.72 | KDR (0.51) | LMNAALDH1A1HPGDALOX15ATG4B | |
| SCHEMBL2821023 | 0.70 | ALDH1A1 (0.46) | ALDH1A1ALOX15MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8654197 | 0.70 | KMT2A (0.48) | ALDH1A1MEN1KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4006241-A | Certain halothien-2-yl 5-nitrothiazol-2-yl ketones and fungicidal composition | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | claimed |
| EP-1343503-B1 | HETEROARYL UREA NEUROPEPTIDE Y Y5 RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2008-11-12 | — | — | EP | disclosed |
| US-7309704-B2 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | SCHERING CORPORATION (US) | 2007-12-18 | — | — | US | disclosed |
| CN-1807426-A | Heteroaryl urea neuropeptide y y5 receptor antagonists | SCHERING CORP (US) | 2006-07-26 | — | — | CN | disclosed |
| US-20060030588-A1 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | SCHERING CORPORATION | 2006-02-09 | — | — | US | disclosed |
| US-6982267-B2 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | SCHERING CORPORATION (US) | 2006-01-03 | — | — | US | disclosed |
| US-6946476-B2 | For therapy of metabolic and eating disorders such as obesity and hyperphagia, diabetes | SCHERING CORPORATION (US) | 2005-09-20 | — | — | US | disclosed |
| CN-1482912-A | Heteroaryl urea neuropeptide yy5 receptor antagonists | ���鹫˾ | 2004-03-17 | — | — | CN | disclosed |
| EP-1343503-A4 | HETEROARYL UREA NEUROPEPTIDE Y Y5 RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2004-03-17 | — | — | EP | disclosed |
| US-20040006086-A1 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | MERCK SHARP & DOHME CORP. | 2004-01-08 | — | — | US | disclosed |
| EP-1343503-A1 | HETEROARYL UREA NEUROPEPTIDE Y Y5 RECEPTOR ANTAGONISTS | Schering Corporation (US) | 2003-09-17 | — | — | EP | disclosed |
| US-20030055062-A1 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | SCHERING CORPORATION | 2003-03-20 | — | — | US | disclosed |
| WO-2002049648-A1 | HETEROARYL UREA NEUROPEPTIDE Y Y5 RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2002-06-27 | — | — | WO | disclosed |
| US-4006241-A | Certain halothien-2-yl 5-nitrothiazol-2-yl ketones and fungicidal composition | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | disclosed |
| US-3835131-A | 2-ACYL-5-NITROTHIAZOLE DERIVATIVES | SCHERING AG | 1974-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055062-A1 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | NPY5R, NPY1R, NPY2R | LMNA 4606/4885ALDH1A1 4694/4885HPGD 3189/4885 |
| US-20040006086-A1 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | NPY5R, NPY1R, NPY2R | LMNA 4606/4885ALDH1A1 4694/4885HPGD 3189/4885 |
| US-20060030588-A1 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | NPY5R, NPY1R, NPY2R | LMNA 4605/4885ALDH1A1 4796/4885HPGD 3095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.