Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.35 |
| ▸ | HTR7 | P34969 | 8/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | HTR6 | P50406 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 4/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734290 | 0.90 | HTR1A (0.35) | HTR1AHTR7DRD2HTR6BRD4 | |
| SCHEMBL4731530 | 0.89 | BRD4 (0.37) | HTR1AHTR7DRD2HTR6BRD4 | |
| SCHEMBL4734123 | 0.87 | HTR1A (0.38) | HTR1AHTR7DRD2HTR6DPP4 | |
| SCHEMBL4782344 | 0.80 | HTR1A (0.37) | HTR1AHTR7DRD2HTR6DPP4 | |
| SCHEMBL4731657 | 0.80 | HTR1A (0.38) | HTR1AHTR7DRD2HTR6DPP4 | |
| SCHEMBL4736394 | 0.79 | TGM2 (0.34) | BRD4 | |
| SCHEMBL4734122 | 0.78 | HTR1A (0.38) | HTR1AHTR7DRD2HTR6DPP4 | |
| SCHEMBL4734165 | 0.76 | TAAR1 (0.40) | — | |
| SCHEMBL4732227 | 0.74 | HTR1A (0.38) | HTR1AHTR7DRD2HTR6BRD4 | |
| SCHEMBL4729713 | 0.74 | HTR1A (0.36) | HTR1AHTR7DRD2HTR6BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |