Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.37 |
| ▸ | HTR7 | P34969 | 10/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | HTR6 | P50406 | 5/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 6/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732731 | 0.86 | CNR2 (0.38) | HTR1AHTR7DRD2HTR6CYP26A1 | |
| SCHEMBL4731657 | 0.85 | HTR1A (0.38) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4733337 | 0.80 | HTR1A (0.35) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4734722 | 0.78 | HCAR3 (0.33) | — | |
| SCHEMBL4735405 | 0.76 | HTR1A (0.39) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4736205 | 0.76 | HTT (0.35) | — | |
| SCHEMBL4735151 | 0.76 | BRD4 (0.35) | HTR6DPP4DPP7KCNH2HDAC8 | |
| SCHEMBL4733825 | 0.74 | SFRP1 (0.46) | HDAC8 | |
| SCHEMBL4797961 | 0.73 | BRD4 (0.36) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL6102384 | 0.73 | HTR1A (0.42) | HTR1AHTR7DRD2HTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |