Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | MARS1 | P56192 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727903 | 0.92 | MAPT (0.39) | KDM4ENPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL4730991 | 0.92 | APOBEC3A (0.33) | APOBEC3AAPOBEC3GKDM4ENPC1LMNA | |
| SCHEMBL4731299 | 0.87 | APOBEC3A (0.35) | APOBEC3AAPOBEC3GAURKADAPK3JAK2 | |
| SCHEMBL4729542 | 0.86 | NPC1 (0.38) | KDM4ENPC1LMNATP53HPGD | |
| SCHEMBL4732555 | 0.85 | APOBEC3A (0.34) | APOBEC3AAPOBEC3GKDM4ENPC1RAB9A | |
| SCHEMBL4730446 | 0.85 | KDM4E (0.38) | KDM4ENPC1TP53RAB9A | |
| SCHEMBL4731095 | 0.84 | S1PR1 (0.36) | MARS1KDM4ENPC1 | |
| SCHEMBL4731314 | 0.83 | APOBEC3A (0.33) | APOBEC3AAPOBEC3GLMNASMN1; SMN2ABL1 | |
| SCHEMBL14223411 | 0.83 | ALDH1A1 (0.33) | APOBEC3AAPOBEC3GMARS1 | |
| SCHEMBL4728477 | 0.83 | SLC6A9 (0.35) | TP53JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | claimed |
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |