Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | RHEB | Q15382 | 3/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11759221 | 0.91 | AGBL2 (0.55) | AGBL2CYP2C9HPGDCYP2C19PTGDR2 | |
| SCHEMBL2391712 | 0.88 | CYP2C9 (0.51) | AGBL2CYP2C9HPGDCYP2C19PTGDR2 | |
| SCHEMBL11343508 | 0.86 | HPGD (0.65) | AGBL2CYP2C9HPGDCYP2C19PTGDR2 | |
| SCHEMBL4731272 | 0.85 | AGBL2 (0.81) | AGBL2CYP2C9HPGDCYP2C19PTGDR2 | |
| SCHEMBL11480110 | 0.85 | AGBL2 (0.52) | AGBL2CYP2C9HPGDCYP2C19PTGDR2 | |
| SCHEMBL11335380 | 0.83 | AGBL2 (0.56) | AGBL2CYP2C9HPGDCYP2C19PTGDR2 | |
| SCHEMBL11759778 | 0.83 | SLC6A9 (0.48) | AGBL2CYP2C9HPGDCYP2C19AKR1C3 | |
| SCHEMBL11338926 | 0.83 | AGBL2 (0.56) | AGBL2CYP2C9HPGDCYP2C19PTGDR2 | |
| SCHEMBL11756903 | 0.83 | AGBL2 (0.66) | AGBL2CYP2C9HPGDCYP2C19PTGDR2 | |
| SCHEMBL11334600 | 0.82 | MMP2 (0.63) | AGBL2CYP2C9HPGDCYP2C19PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |