Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 11/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821700 | 0.83 | CNR2 (0.49) | CACNA1HAOC3MAPK14LTB4R2PDK1 | |
| SCHEMBL4737075 | 0.83 | MAPK14 (0.40) | MAPK14LTB4R2PDK1PDK2PDK3 | |
| SCHEMBL4785417 | 0.82 | CACNA1H (0.41) | CACNA1HAOC3MAPK14LTB4R2PDK1 | |
| SCHEMBL4733787 | 0.82 | KMT2A (0.48) | CACNA1H | |
| SCHEMBL4736030 | 0.81 | CACNA1H (0.47) | CACNA1HAOC3MAPK14LTB4R2CNR2 | |
| SCHEMBL3071006 | 0.81 | CACNA1H (0.47) | CACNA1HAOC3MAPK14LTB4R2GRIA2 | |
| Trifluoroacetic Acid SCHEMBL3825726 | 0.79 | CNR2 (0.44) | CACNA1HAOC3MAPK14LTB4R2PDK1 | |
| SCHEMBL3064331 | 0.78 | CACNA1H (0.45) | CACNA1HAOC3LTB4R2GRIA2GRIN1 | |
| SCHEMBL3815393 | 0.78 | CACNA1H (0.45) | CACNA1HAOC3LTB4R2GRIN1GRIN2A | |
| SCHEMBL4734213 | 0.78 | LMNA (0.54) | CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |