Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3066627 | 0.86 | LMNA (0.47) | MAPTLMNAGAACACNA1HTP53 | |
| SCHEMBL4738921 | 0.82 | TRPM8 (0.43) | CACNA1HTRPM8 | |
| SCHEMBL4733659 | 0.82 | CACNA1H (0.41) | CACNA1H | |
| SCHEMBL4736030 | 0.81 | CACNA1H (0.47) | KMT2AMEN1TSHRCACNA1HALDH1A1 | |
| SCHEMBL3071006 | 0.81 | CACNA1H (0.47) | KMT2AMEN1MAPTLMNACACNA1H | |
| SCHEMBL4734213 | 0.80 | LMNA (0.54) | KMT2AMEN1MAPTLMNAGAA | |
| SCHEMBL3821700 | 0.79 | CNR2 (0.49) | GAACACNA1H | |
| SCHEMBL8186704 | 0.79 | HPGD (0.41) | MAPTLMNACACNA1HKDM4E | |
| SCHEMBL4736795 | 0.79 | CACNA1H (0.43) | MAPTLMNACACNA1HRAB9ANPC1 | |
| SCHEMBL4737551 | 0.79 | ALDH1A1 (0.44) | MAPTLMNAGAACACNA1HTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |