Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736687 | 0.94 | MAPT (0.48) | MAPTNPC1RAB9ANFKB1MAPK1 | |
| SCHEMBL4736909 | 0.88 | MAPT (0.56) | MAPTNPC1RAB9ANFKB1MAPK1 | |
| SCHEMBL4736967 | 0.88 | TDP1 (0.44) | MAPTNPC1RAB9ANFKB1MAPK1 | |
| SCHEMBL4735581 | 0.87 | ITGB1 (0.46) | MAPTNPC1RAB9ANFKB1MAPK1 | |
| SCHEMBL4736256 | 0.85 | ITGB1 (0.44) | MAPTNPC1RAB9ANFKB1MAPK1 | |
| SCHEMBL4739188 | 0.83 | ITGB1 (0.45) | MAPTNPC1RAB9ANFKB1MAPK1 | |
| SCHEMBL4786471 | 0.83 | ITGB1 (0.44) | ITGB1ITGA4 | |
| SCHEMBL6532346 | 0.82 | ITGB1 (0.41) | MAPTITGB1ITGA4ALDH1A1CRHBP | |
| SCHEMBL4737759 | 0.81 | KMT2A (0.39) | MAPTMAPK1ITGB1ITGA4ALDH1A1 | |
| SCHEMBL3832796 | 0.81 | ITGB1 (0.47) | MAPTITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064830-A1 | BICYCLIC AND HETEROBICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR PHARMACEUTICAL USES | UCB PHARMA, S.A. (BE) | 2008-06-05 | — | — | WO | disclosed |