Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733784 | 0.88 | MAPT (0.52) | ITGB1ITGA4MAPTNPC1RAB9A | |
| SCHEMBL4736256 | 0.85 | ITGB1 (0.44) | ITGB1ITGA4MAPTNPC1RAB9A | |
| SCHEMBL6532346 | 0.84 | ITGB1 (0.41) | ITGB1ITGA4MAPTKDM4EALDH1A1 | |
| SCHEMBL4737637 | 0.84 | ITGB1 (0.42) | ITGB1ITGA4ALDH1A1 | |
| SCHEMBL4737759 | 0.83 | KMT2A (0.39) | ITGB1ITGA4MAPTMAPK1ALDH1A1 | |
| SCHEMBL4736687 | 0.82 | MAPT (0.48) | ITGB1ITGA4MAPTNPC1RAB9A | |
| SCHEMBL4735581 | 0.78 | ITGB1 (0.46) | ITGB1ITGA4MAPTNPC1RAB9A | |
| SCHEMBL3835880 | 0.78 | ITGB1 (0.46) | TDP1ITGB1ITGA4MAPTRAB9A | |
| SCHEMBL3832796 | 0.78 | ITGB1 (0.47) | ITGB1ITGA4MAPTKDM4E | |
| SCHEMBL4736909 | 0.77 | MAPT (0.56) | ITGB1ITGA4MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064830-A1 | BICYCLIC AND HETEROBICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR PHARMACEUTICAL USES | UCB PHARMA, S.A. (BE) | 2008-06-05 | — | — | WO | claimed |
| WO-2008064830-A1 | BICYCLIC AND HETEROBICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR PHARMACEUTICAL USES | UCB PHARMA, S.A. (BE) | 2008-06-05 | — | — | WO | disclosed |