Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 7/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735983 | 0.87 | ITGA4 (0.47) | ITGB1ITGA4 | |
| SCHEMBL4737759 | 0.86 | KMT2A (0.39) | ITGB1ITGA4HTTGAAALDH1A1 | |
| SCHEMBL4736967 | 0.85 | TDP1 (0.44) | ITGB1ITGA4ALDH1A1RAB9AKMT2A | |
| SCHEMBL4733784 | 0.85 | MAPT (0.52) | ITGB1ITGA4ALDH1A1RAB9AKMT2A | |
| SCHEMBL4737693 | 0.83 | ITGB1 (0.43) | ITGB1ITGA4 | |
| SCHEMBL4732917 | 0.82 | ITGB1 (0.47) | ITGB1ITGA4ALDH1A1RAB9AKMT2A | |
| SCHEMBL6532346 | 0.82 | ITGB1 (0.41) | ITGB1ITGA4GAAALDH1A1KMT2A | |
| SCHEMBL3835880 | 0.81 | ITGB1 (0.46) | ITGB1ITGA4GAAALDH1A1RAB9A | |
| SCHEMBL3832796 | 0.81 | ITGB1 (0.47) | ITGB1ITGA4MAPT | |
| SCHEMBL4736687 | 0.79 | MAPT (0.48) | ITGB1ITGA4ALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064830-A1 | BICYCLIC AND HETEROBICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR PHARMACEUTICAL USES | UCB PHARMA, S.A. (BE) | 2008-06-05 | — | — | WO | claimed |
| WO-2008064830-A1 | BICYCLIC AND HETEROBICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR PHARMACEUTICAL USES | UCB PHARMA, S.A. (BE) | 2008-06-05 | — | — | WO | disclosed |