Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 7/20 | 0.36 |
| ▸ | BRD2 | P25440 | 4/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783144 | 0.90 | HTT (0.46) | HTTBRD4BRD2BRD3TP53 | |
| SCHEMBL4733255 | 0.87 | BRD4 (0.44) | KDM4EHTTBRD4BRD2BRD3 | |
| SCHEMBL4732992 | 0.87 | CA1 (0.40) | KDM4EHTTBRD4BRD2BRD3 | |
| SCHEMBL4733897 | 0.85 | CNR2 (0.40) | HTTTP53TSHRCCR8 | |
| SCHEMBL4733373 | 0.83 | BRD4 (0.40) | KDM4EBRD4TP53LMNATSHR | |
| SCHEMBL4736205 | 0.79 | HTT (0.35) | HTTBRD4BRD2BRD3TP53 | |
| SCHEMBL4796518 | 0.79 | KDM4E (0.33) | KDM4EHTTBRD4GAA | |
| SCHEMBL4732186 | 0.77 | HTT (0.36) | HTTBRD4BRD2BRD3TP53 | |
| SCHEMBL4729711 | 0.77 | ALDH1A1 (0.52) | KDM4ETSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL4732359 | 0.77 | BRD4 (0.36) | HTTBRD4BRD2BRD3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |