Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 4/20 | 0.42 |
| ▸ | BRD2 | P25440 | 2/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733893 | 0.90 | KDM4E (0.38) | HTTMAPTLMNAGAATSHR | |
| SCHEMBL4733255 | 0.90 | BRD4 (0.44) | HTTMAPTLMNAGAATSHR | |
| SCHEMBL4732992 | 0.90 | CA1 (0.40) | HTTLMNATP53BRD4BRD2 | |
| SCHEMBL4730927 | 0.78 | LMNA (0.41) | LMNAGAA | |
| SCHEMBL4733897 | 0.77 | CNR2 (0.40) | HTTTSHRTP53 | |
| SCHEMBL4733822 | 0.76 | SFRP1 (0.50) | HTTALDH1A1L3MBTL1BRD4BRD2 | |
| SCHEMBL4733373 | 0.75 | BRD4 (0.40) | LMNATSHRALDH1A1L3MBTL1TP53 | |
| SCHEMBL4733929 | 0.75 | PARG (0.39) | HTTMAPTLMNATP53MEN1 | |
| SCHEMBL4731045 | 0.73 | LMNA (0.38) | MAPTLMNATSHRALDH1A1L3MBTL1 | |
| SCHEMBL4735405 | 0.73 | HTR1A (0.39) | HTTLMNAGAATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |