Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783250 | 0.83 | MAOB (0.39) | MAOBPARP1CES2CES1ABCC9 | |
| SCHEMBL4783710 | 0.79 | MAOB (0.51) | MAOBCES2CES1NPC1RAB9A | |
| SCHEMBL4784686 | 0.72 | CTNNB1 (0.54) | MAOBCES2CES1PGRNPC1 | |
| SCHEMBL4735516 | 0.68 | — | — | |
| SCHEMBL4844028 | 0.68 | ALDH1A1 (0.40) | SLC22A12XDHNPC1RAB9AMAPT | |
| SCHEMBL16742098 | 0.65 | TTR (0.46) | SLC22A12XDHPARP1MAPTNPSR1 | |
| SCHEMBL4784600 | 0.65 | IDO1 (0.57) | CES2CES1PGRRAB9A | |
| SCHEMBL10884184 | 0.65 | NPC1 (0.42) | MAOBCES2CES1PGRS1PR3 | |
| SCHEMBL13263896 | 0.65 | CES2 (0.53) | MAOBCES2CES1NPC1RAB9A | |
| SCHEMBL2086107 | 0.64 | HSD11B1 (0.41) | PGRS1PR3NPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076043-A1 | NOVEL 2-AMINO-5,5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076043-A1 | NOVEL 2-AMINO-5,5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |