SCHEMBL4734137

SCHEMBL4734137

CC1(C)c2ccc(F)cc2S(O)(O)c2cc(S(=O)(=O)NC3CCN(C(=O)O)CC3)c(C(F)(F)F)cc21

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SFRP1 Q8N474 20/20 0.43
WNT3 P56703 6/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4733107 0.93 SFRP1 (0.43) SFRP1WNT3
SCHEMBL4730846 0.88 DPP4 (0.39) SFRP1
SCHEMBL4734145 0.85 SFRP1 (0.45) SFRP1WNT3
SCHEMBL4730501 0.81 DPP4 (0.39) SFRP1
SCHEMBL4735477 0.81 DPP4 (0.36) SFRP1WNT3
SCHEMBL4734140 0.80 SFRP1 (0.45) SFRP1WNT3
SCHEMBL4732277 0.79 SFRP1 (0.52) SFRP1WNT3
SCHEMBL4730172 0.79 SFRP1 (0.42) SFRP1WNT3
SCHEMBL4733825 0.78 SFRP1 (0.46) SFRP1WNT3
SCHEMBL4730240 0.78 CCR8 (0.39) SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061029-A1 ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2008-05-22 WO disclosed