Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 6/20 | 0.35 |
| ▸ | WNT3 | P56703 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730171 | 0.91 | SFRP1 (0.42) | CYP3A4CYP2C19SFRP1WNT3 | |
| SCHEMBL4733107 | 0.88 | SFRP1 (0.43) | SFRP1WNT3 | |
| SCHEMBL4730501 | 0.86 | DPP4 (0.39) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL4732376 | 0.86 | WNT3 (0.36) | SFRP1WNT3DRD2HTR6 | |
| SCHEMBL4730172 | 0.85 | SFRP1 (0.42) | CYP3A4CYP2C19SFRP1WNT3 | |
| SCHEMBL4734137 | 0.81 | SFRP1 (0.43) | SFRP1WNT3 | |
| SCHEMBL4730846 | 0.79 | DPP4 (0.39) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL4730237 | 0.76 | MEN1 (0.39) | CYP3A4CYP2C19SFRP1WNT3 | |
| SCHEMBL4731674 | 0.76 | PTGDR2 (0.33) | — | |
| SCHEMBL4731040 | 0.75 | SFRP1 (0.42) | DPP4DPP7KCNH2SFRP1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |