Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 7/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | WNT3 | P56703 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730171 | 0.94 | SFRP1 (0.42) | SFRP1CCR8BRD4STSMMP13 | |
| SCHEMBL4735477 | 0.85 | DPP4 (0.36) | SFRP1WNT3CYP3A4CYP2C19 | |
| SCHEMBL4734137 | 0.79 | SFRP1 (0.43) | SFRP1WNT3 | |
| SCHEMBL4732376 | 0.77 | WNT3 (0.36) | SFRP1BRD4WNT3 | |
| SCHEMBL4730846 | 0.77 | DPP4 (0.39) | SFRP1CCR8CYP3A4CYP2C19 | |
| SCHEMBL4732381 | 0.77 | CCR8 (0.45) | SFRP1CCR8BRD4STSMMP13 | |
| SCHEMBL4407578 | 0.76 | CCR8 (0.56) | SFRP1CCR8BRD4MMP13 | |
| SCHEMBL4732371 | 0.75 | SFRP1 (0.50) | SFRP1CCR8BRD4STSWNT3 | |
| SCHEMBL4735919 | 0.75 | MCHR1 (0.51) | SFRP1CCR8BRD4STSWNT3 | |
| SCHEMBL4883255 | 0.73 | SFRP1 (0.59) | SFRP1CCR8BRD4STSMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |