Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 6/20 | 0.41 |
| ▸ | CNR1 | P21554 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730027 | 0.91 | CNR2 (0.42) | CNR2CNR1KMT2ANAMPTRAB9A | |
| SCHEMBL4733445 | 0.78 | RAB9A (0.40) | CNR2CNR1KMT2ANAMPTRAB9A | |
| SCHEMBL4733798 | 0.74 | CNR2 (0.45) | CNR2CNR1RAB9AALDH1A1KDM4E | |
| SCHEMBL4731510 | 0.73 | CNR2 (0.55) | CNR2CNR1KMT2ARAB9AALDH1A1 | |
| SCHEMBL14206637 | 0.72 | CNR2 (0.54) | CNR2CNR1KMT2AALDH1A1MEN1 | |
| SCHEMBL14206962 | 0.72 | CNR2 (0.45) | CNR2CNR1KMT2AMEN1 | |
| SCHEMBL14206662 | 0.71 | CNR2 (0.56) | CNR2CNR1LMNA | |
| SCHEMBL4734563 | 0.69 | CNR2 (0.54) | CNR2CNR1ARALDH1A1LMNA | |
| SCHEMBL4733925 | 0.69 | CNR2 (0.51) | CNR2CNR1LMNA | |
| SCHEMBL4731889 | 0.68 | CNR2 (0.56) | CNR2CNR1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | claimed |
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |