Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 7/20 | 0.49 |
| ▸ | RARG | P13631 | 7/20 | 0.49 |
| ▸ | RARA | P10276 | 6/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542625 | 0.76 | RARB (0.71) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL3547915 | 0.76 | RARB (0.63) | RARBRARGRARAPTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL11212968 | 0.75 | RARB (0.69) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL11212966 | 0.75 | RARB (0.58) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL4734952 | 0.74 | MAOB (0.40) | RXRAMAOBCES2CES1 | |
| SCHEMBL4737812 | 0.72 | PKM (0.43) | RXRAMAOBCES2CES1NPC1 | |
| SCHEMBL5656242 | 0.72 | RARB (0.55) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL16744298 | 0.72 | RARB (0.73) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL5658641 | 0.72 | PTGS2 (0.64) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL5654554 | 0.72 | RARB (0.55) | RARBRARGRARAPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |