Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737812 | 0.88 | PKM (0.43) | MAOBCES2CES1SSTR5MAPT | |
| SCHEMBL10407993 | 0.77 | MAPT (0.44) | HTR2ASSTR5MAPTAKR1B1ALDH1A1 | |
| SCHEMBL2812534 | 0.76 | RXRA (0.52) | SSTR5MAPTAKR1B1ALDH1A1RXRA | |
| SCHEMBL103150 | 0.76 | MAPT (0.47) | SSTR5MAPTAKR1B1ALDH1A1RXRA | |
| SCHEMBL31417802 | 0.75 | GPR183 (0.34) | MAOBHTR2ASSTR5MAPTALDH1A1 | |
| SCHEMBL31417694 | 0.75 | GPR183 (0.34) | MAOBHTR2ASSTR5MAPTALDH1A1 | |
| SCHEMBL4783710 | 0.75 | MAOB (0.51) | MAOBCES2CES1MAPT | |
| SCHEMBL4734533 | 0.74 | RARB (0.49) | MAOBCES2CES1RXRA | |
| SCHEMBL4785756 | 0.74 | CTNNB1 (0.49) | MAOBCES2CES1 | |
| SCHEMBL4784496 | 0.74 | CES2 (0.43) | MAOBCES2CES1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |