Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783727 | 0.88 | MEN1 (0.36) | CYP17A1PTGS2OPRK1PDE4DMEN1 | |
| SCHEMBL4737261 | 0.82 | PTGS2 (0.44) | CYP17A1PTGS2OPRK1PDE4DMEN1 | |
| SCHEMBL29670758 | 0.81 | PTGS2 (0.50) | CYP17A1PTGS2OPRK1PDE4DHTR2C | |
| SCHEMBL170423 | 0.81 | PTGS2 (0.50) | CYP17A1PTGS2OPRK1PDE4DHTR2C | |
| SCHEMBL11182451 | 0.80 | ALDH1A1 (0.41) | MEN1HTTKMT2ANOX1RAD52 | |
| SCHEMBL28373276 | 0.80 | PTGS2 (0.49) | CYP17A1PTGS2OPRK1PDE4DHTR2C | |
| SCHEMBL11825628 | 0.77 | PTGS2 (0.39) | CYP17A1PTGS2OPRK1PDE4DHTR2A | |
| SCHEMBL4733314 | 0.76 | RAD52 (0.44) | HTR2AHTR2CHTTNOX1MAPT | |
| SCHEMBL29756225 | 0.76 | NOX1 (0.38) | MEN1KMT2ANOX1MAPTRAD52 | |
| SCHEMBL11831309 | 0.75 | PTGS2 (0.62) | PTGS2OPRK1PDE4DHTR2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |