Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 7/20 | 0.66 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.66 |
| ▸ | ESR1 | P03372 | 4/20 | 0.66 |
| ▸ | NQO2 | P16083 | 4/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.66 |
| ▸ | TTR | P02766 | 3/20 | 0.66 |
| ▸ | AHR | P35869 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.66 |
| ▸ | BCR | P11274 | 2/20 | 0.66 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.66 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.66 |
| ▸ | TUBB | P07437 | 2/20 | 0.66 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.66 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.66 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.66 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.66 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736118 | 1.00 | CYP1A1 (0.66) | CYP1A1CYP1B1PTGS2ESR1NQO2 | |
| SCHEMBL741474 | 0.90 | INPPL1 (0.59) | CYP1A1CYP1B1PTGS2ESR1NQO2 | |
| SCHEMBL14175313 | 0.83 | TUBB1 (0.67) | CYP1A1CYP1B1PTGS2NQO2CYP1A2 | |
| SCHEMBL30340032 | 0.81 | PTGS1 (0.58) | CYP1A1CYP1B1PTGS2ESR1NQO2 | |
| Trismethoxyresveratrol SCHEMBL918740 | 0.80 | CYP1A1 (1.00) | CYP1A1CYP1B1PTGS2ESR1NQO2 | |
| Trismethoxyresveratrol SCHEMBL918739 | 0.80 | CYP1A1 (1.00) | CYP1A1CYP1B1PTGS2ESR1NQO2 | |
| 8Z-3,4',5-Trimethoxystilbene SCHEMBL1006207 | 0.80 | CYP1A1 (1.00) | CYP1A1CYP1B1PTGS2ESR1NQO2 | |
| SCHEMBL12205333 | 0.79 | INPPL1 (0.46) | CYP1A1CYP1B1PTGS2ESR1NQO2 | |
| SCHEMBL3219196 | 0.78 | SRC (0.60) | — | |
| SCHEMBL27799416 | 0.78 | INPPL1 (0.76) | CYP1A1CYP1B1CYP1A2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178704-A1 | PREVENTION AND TREATMENT OF COLON CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2012-07-12 | — | — | US | claimed |
| WO-2008070872-A1 | PREVENTION AND TREATMENT OF COLON CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2008-06-12 | — | — | WO | claimed |
| US-8426369-B2 | Prevention and treatment of colon cancer | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2013-04-23 | — | — | US | disclosed |
| US-20120178704-A1 | PREVENTION AND TREATMENT OF COLON CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2012-07-12 | — | — | US | disclosed |
| WO-2008070872-A1 | PREVENTION AND TREATMENT OF COLON CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178704-A1 | PREVENTION AND TREATMENT OF COLON CANCER | APC, SI, NFKBIA | CYP1A1 1123/4885CYP1B1 1133/4885PTGS2 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.