Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735509 | 0.81 | NSD3 (0.44) | PLATHTR2CCYP1A2CYP2C19HTR2B | |
| Hydrochloric Acid SCHEMBL3868559 | 0.80 | NSD3 (0.43) | PLATHTR2CCYP1A2CYP2C19HTR2B | |
| SCHEMBL3858769 | 0.74 | PLAT (0.41) | PLATHTR2CCYP1A2CYP2C19HTR2B | |
| SCHEMBL4785266 | 0.72 | PLAT (0.48) | PLATHTR2CCYP1A2TDP1CYP2C19 | |
| Hydrochloric Acid SCHEMBL3250146 | 0.71 | HTR2C (0.48) | PLATHTR2CCYP1A2TDP1CYP2C19 | |
| SCHEMBL3959958 | 0.71 | HTR2C (0.48) | PLATHTR2CCYP1A2TDP1CYP2C19 | |
| SCHEMBL6039495 | 0.69 | CYP1A2 (0.49) | PLATHTR2CCYP1A2TDP1CYP2C19 | |
| SCHEMBL27425885 | 0.68 | HTR2C (0.42) | PLATHTR2CCYP1A2TDP1CYP2C19 | |
| SCHEMBL5498692 | 0.68 | NSD3 (0.37) | HTR2CTDP1HTR2BHTR2AALDH1A1 | |
| SCHEMBL6208933 | 0.65 | CES2 (0.57) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008070014-A2 | BIARYL KETONE-SUBSTITUTED PIPERIDINES | NEUROGEN CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |