Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | DRD3 | P35462 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | HTR7 | P34969 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736483 | 0.88 | TSHR (0.47) | TSHRGAAHTR2ADRD3HTR1A | |
| SCHEMBL4733572 | 0.87 | TSHR (0.45) | TSHRGAAOPRM1OPRK1ALDH1A1 | |
| SCHEMBL4735150 | 0.87 | TSHR (0.51) | TSHRGAAOPRM1OPRK1ALDH1A1 | |
| SCHEMBL4738289 | 0.86 | GAA (0.45) | TSHRGAAOPRM1KDM4ESMO | |
| SCHEMBL4737126 | 0.86 | TSHR (0.48) | TSHRGAAHTR2ADRD3HTR1A | |
| SCHEMBL4735433 | 0.86 | OPRM1 (0.40) | TSHRHTR2ADRD3HTR1ADRD4 | |
| SCHEMBL4785409 | 0.85 | TSHR (0.52) | TSHRGAAHTR2ADRD3HTR1A | |
| SCHEMBL4738239 | 0.85 | TSHR (0.49) | TSHRGAAHTR2ADRD3HTR1A | |
| SCHEMBL4737945 | 0.85 | OPRM1 (0.44) | TSHRHTR2ADRD3HTR1ADRD4 | |
| SCHEMBL4735235 | 0.84 | GAA (0.47) | TSHRGAAOPRM1KDM4ESMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |