Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 6/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785360 | 0.87 | LMNA (0.46) | OPRM1LMNAKDM4ETSHRALDH1A1 | |
| SCHEMBL4735444 | 0.86 | LMNA (0.52) | OPRM1LMNAKDM4ETSHRALDH1A1 | |
| SCHEMBL4738686 | 0.86 | OPRM1 (0.55) | OPRM1LMNADRD3DRD2HTR1A | |
| SCHEMBL4734088 | 0.85 | LMNA (0.53) | OPRM1LMNAKDM4ETSHRALDH1A1 | |
| SCHEMBL4735626 | 0.85 | TSHR (0.42) | OPRM1DRD3DRD2HTR1AHTR2A | |
| SCHEMBL4735586 | 0.85 | LMNA (0.53) | OPRM1LMNAKDM4ETSHRALDH1A1 | |
| SCHEMBL4736215 | 0.84 | LMNA (0.48) | OPRM1LMNAKDM4ETSHRALDH1A1 | |
| SCHEMBL4735594 | 0.84 | OPRM1 (0.48) | OPRM1LMNADRD3DRD2HTR1A | |
| SCHEMBL4735433 | 0.83 | OPRM1 (0.40) | OPRM1DRD3DRD2HTR1AHTR2A | |
| SCHEMBL4738710 | 0.82 | LMNA (0.49) | OPRM1LMNADRD3DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |