Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738360 | 0.87 | — | — | |
| SCHEMBL4737618 | 0.83 | CYP3A4 (0.36) | CYP3A4CYP2C19SIRT2SIRT1ELANE | |
| SCHEMBL4734701 | 0.83 | ALDH1A1 (0.38) | CYP3A4CYP2C19SIRT2SIRT1ELANE | |
| SCHEMBL4737293 | 0.74 | ALDH1A1 (0.37) | CYP3A4CYP2C19ELANEPRTN3 | |
| SCHEMBL4737295 | 0.74 | ALDH1A1 (0.37) | CYP3A4CYP2C19ELANEPRTN3 | |
| SCHEMBL4737617 | 0.72 | TSHR (0.33) | CYP2C19 | |
| SCHEMBL4739265 | 0.70 | — | — | |
| SCHEMBL4739806 | 0.68 | HSP90AA1 (0.34) | ELANEPRTN3 | |
| SCHEMBL5116642 | 0.67 | GAA (0.43) | SIRT2SIRT1 | |
| SCHEMBL4664863 | 0.65 | LMNA (0.40) | CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |