Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | PKLR | P30613 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740396 | 0.92 | LMNA (0.51) | AKR1C3AKR1C1LMNASMN1; SMN2CYP2C19 | |
| SCHEMBL4736709 | 0.89 | LMNA (0.57) | MAPTLMNASMN1; SMN2CYP2C19DPP4 | |
| SCHEMBL4737593 | 0.89 | LMNA (0.57) | MAPTLMNASMN1; SMN2CYP2C19DPP4 | |
| SCHEMBL4741627 | 0.88 | CYP2C19 (0.59) | AKR1C3AKR1C1LMNASMN1; SMN2CYP2C19 | |
| SCHEMBL4741087 | 0.86 | AKR1C3 (0.48) | AKR1C3AKR1C1MAPTLMNADPP4 | |
| SCHEMBL4737612 | 0.85 | LMNA (0.50) | AKR1C3AKR1C1LMNASMN1; SMN2CYP2C19 | |
| SCHEMBL4738276 | 0.84 | CYP2C19 (0.52) | MAPTLMNASMN1; SMN2CYP2C19DPP4 | |
| SCHEMBL4738968 | 0.84 | HSD11B1 (0.58) | AKR1C3AKR1C1MAPTCYP2C19PKLR | |
| SCHEMBL4738286 | 0.83 | LMNA (0.55) | LMNASMN1; SMN2CYP2C19DPP4ALDH1A1 | |
| SCHEMBL4736675 | 0.83 | MEN1 (0.54) | MAPTLMNASMN1; SMN2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |