Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738239 | 0.96 | TSHR (0.49) | TSHRGAAPDK1OPRM1OPRK1 | |
| SCHEMBL4735150 | 0.91 | TSHR (0.51) | TSHRGAAPDK1OPRM1OPRK1 | |
| SCHEMBL4737126 | 0.89 | TSHR (0.48) | TSHRGAAPDK1OPRM1OPRK1 | |
| SCHEMBL4736584 | 0.88 | TSHR (0.51) | TSHRGAAPDK1OPRM1OPRK1 | |
| SCHEMBL4739086 | 0.88 | TSHR (0.52) | TSHRGAAPDK1CXCR2HTT | |
| SCHEMBL3830332 | 0.87 | MEN1 (0.45) | TSHRGAAOPRM1OPRK1CXCR2 | |
| SCHEMBL4736483 | 0.87 | TSHR (0.47) | TSHRGAAPDK1OPRM1OPRK1 | |
| SCHEMBL8185382 | 0.87 | RAB9A (0.48) | PDK1OPRM1OPRK1HTR1ADRD2 | |
| SCHEMBL4735615 | 0.86 | MAPK14 (0.45) | TSHROPRM1OPRK1CXCR2HTR1A | |
| SCHEMBL4736473 | 0.86 | OPRM1 (0.41) | TSHROPRM1OPRK1CXCR2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |