Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738899 | 0.76 | DYRK1A (0.45) | NTRK1LRRK2DYRK1A | |
| SCHEMBL4736970 | 0.75 | NR3C1 (0.53) | — | |
| SCHEMBL4733514 | 0.69 | DYRK1A (0.66) | MAP2K4LRRK2DYRK1APIM1CLK2 | |
| SCHEMBL10770756 | 0.69 | SLC6A2 (0.41) | — | |
| Hydrochloric Acid SCHEMBL10771402 | 0.68 | SLC6A2 (0.40) | — | |
| SCHEMBL23626987 | 0.65 | KDR (0.53) | LRRK2DYRK1ATTK | |
| SCHEMBL23626988 | 0.64 | KDR (0.75) | — | |
| SCHEMBL1677867 | 0.63 | LOXL2 (0.52) | — | |
| SCHEMBL22229846 | 0.63 | LOXL2 (0.52) | — | |
| SCHEMBL31223729 | 0.63 | LOXL2 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |