Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 4/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735202 | 0.77 | DYRK1A (0.45) | DYRK1AMAPK1CYP1A2AAK1MAPK3 | |
| SCHEMBL4737074 | 0.76 | NTRK1 (0.43) | DYRK1ANTRK1LRRK2 | |
| SCHEMBL4738893 | 0.72 | SMO (0.47) | — | |
| SCHEMBL21591549 | 0.72 | LMNA (0.56) | — | |
| SCHEMBL995999 | 0.69 | LIPG (0.45) | MAPK1CYP1A2AAK1 | |
| SCHEMBL27721561 | 0.69 | SCN9A (0.40) | MAPK1CYP1A2 | |
| SCHEMBL10981741 | 0.68 | CTSK (0.62) | MAPK1CYP1A2 | |
| SCHEMBL10974978 | 0.68 | CTSK (0.62) | MAPK1CYP1A2 | |
| SCHEMBL28535891 | 0.68 | ACACB (0.43) | — | |
| SCHEMBL28733236 | 0.68 | CTSK (0.62) | MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |