Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.34 |
| ▸ | PRKACG | P22612 | 2/20 | 0.34 |
| ▸ | PRKACB | P22694 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3483387 | 0.84 | CNR2 (0.40) | CNR2CNR1MEN1KMT2AALDH1A1 | |
| SCHEMBL3483123 | 0.81 | CNR2 (0.37) | CNR2CNR1MEN1KMT2AALDH1A1 | |
| SCHEMBL4250504 | 0.79 | CNR2 (0.38) | CNR2CNR1DYRK1ANFATC1GSK3B | |
| SCHEMBL3483421 | 0.79 | MEN1 (0.33) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL3653448 | 0.78 | CNR2 (0.47) | CNR2CNR1NPSR1MEN1KMT2A | |
| SCHEMBL27757527 | 0.78 | CNR2 (0.40) | CNR2CNR1 | |
| SCHEMBL4604002 | 0.78 | CNR2 (0.55) | CNR2CNR1NPSR1GSK3BMEN1 | |
| SCHEMBL3450091 | 0.76 | ALDH1A1 (0.46) | CNR2CNR1NPSR1MEN1KMT2A | |
| SCHEMBL3376301 | 0.75 | LMNA (0.49) | CNR2CNR1MEN1KMT2AALDH1A1 | |
| SCHEMBL2596719 | 0.73 | IMPDH2 (0.35) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |