Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP5 | P45974 | 5/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738276 | 0.89 | CYP2C19 (0.52) | CYP2C19LMNASMN1; SMN2CYP3A4MEN1 | |
| SCHEMBL4736709 | 0.89 | LMNA (0.57) | CYP2C19HDAC6LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL4737593 | 0.89 | LMNA (0.57) | CYP2C19HDAC6LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL4736675 | 0.87 | MEN1 (0.54) | CYP2C19LMNASMN1; SMN2CYP3A4MEN1 | |
| SCHEMBL4738286 | 0.86 | LMNA (0.55) | CYP2C19HDAC6LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL4737612 | 0.85 | LMNA (0.50) | CYP2C19HDAC6LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL4739751 | 0.85 | HSD11B1 (0.54) | USP5CYP2C19HDAC6LMNATSHR | |
| SCHEMBL4741627 | 0.83 | CYP2C19 (0.59) | CYP2C19HDAC6LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL4736640 | 0.83 | AKR1C3 (0.55) | CYP2C19LMNASMN1; SMN2DPP4 | |
| SCHEMBL4740625 | 0.81 | LMNA (0.57) | CYP2C19LMNASMN1; SMN2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |