Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741721 | 0.91 | KMT2A (0.50) | ALDH1A1MAPTEPHX2MEN1KMT2A | |
| SCHEMBL4738918 | 0.86 | CYP3A4 (0.67) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL4736676 | 0.86 | CYP3A4 (0.51) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL4738964 | 0.86 | POLB (0.51) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL4739860 | 0.86 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL4740143 | 0.86 | CYP3A4 (0.67) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL4737593 | 0.85 | LMNA (0.57) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL4736709 | 0.85 | LMNA (0.57) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL4741708 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL4739753 | 0.84 | CYP3A4 (0.68) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |