Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737532 | 0.85 | GAA (0.51) | NTRK1AURKAABL1LCKCSF1R | |
| SCHEMBL3058922 | 0.85 | HRH4 (0.53) | NTRK1AURKAABL1LCKCSF1R | |
| Hydrochloric Acid SCHEMBL3826981 | 0.84 | HRH4 (0.52) | NTRK1AURKAABL1LCKCSF1R | |
| SCHEMBL3063613 | 0.82 | DRD2 (0.54) | NTRK1AURKAABL1LCKCSF1R | |
| SCHEMBL22279049 | 0.81 | P4HTM (0.51) | ALOX12LMNAGAAL3MBTL1KDM4E | |
| SCHEMBL22279043 | 0.80 | P4HTM (0.50) | ALOX12LMNAGAAL3MBTL1KDM4E | |
| SCHEMBL27477677 | 0.80 | GAA (0.62) | ALOX12LMNAMAOBGAAL3MBTL1 | |
| SCHEMBL14303892 | 0.78 | TAAR1 (0.46) | BPTFNTRK1AURKARETMET | |
| SCHEMBL22279048 | 0.78 | GAA (0.55) | ALOX12LMNAGAAL3MBTL1KDM4E | |
| SCHEMBL1594249 | 0.77 | PLD1 (0.53) | BPTFDDB1CRBNHTR6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |