Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737532 | 0.94 | GAA (0.51) | GAAMAPTRAB9AKDM4ENPC1 | |
| SCHEMBL22279049 | 0.88 | P4HTM (0.51) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL22279043 | 0.86 | P4HTM (0.50) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL2449960 | 0.85 | RAB9A (0.70) | GAAMAPTRAB9AKDM4ENPC1 | |
| SCHEMBL22279027 | 0.84 | RXFP1 (0.48) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL22279054 | 0.84 | KDM4E (0.57) | GAAMAPTRAB9AKDM4ENPC1 | |
| SCHEMBL22279042 | 0.83 | P4HTM (0.47) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL22279046 | 0.79 | GAA (0.46) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL21917393 | 0.79 | MAPT (0.54) | GAAMAPTRAB9AKDM4ENPC1 | |
| SCHEMBL31610745 | 0.78 | ALDH1A1 (0.59) | GAAMAPTRAB9AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020151686-A1 | N-HETEROARYL SULFONAMIDE DERIVATIVE, PREPARATION AND USE THEREOF IN TREATMENT OF AUTOIMMUNE DISEASES | 杭州壹瑞医药科技有限公司 | 2020-07-30 | — | — | WO | disclosed |