Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3483496 | 0.83 | MEN1 (0.45) | ALDH1A1SMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL3483348 | 0.81 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL3482974 | 0.79 | KDM4E (0.40) | ALDH1A1SMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL27761685 | 0.79 | HTR6 (0.43) | HPGDALDH1A1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL9581422 | 0.78 | TP53 (0.54) | HPGDALDH1A1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL10753662 | 0.76 | KDM4E (0.45) | HPGDALDH1A1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL3198506 | 0.75 | GLO1 (0.39) | ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10 | |
| SCHEMBL31735581 | 0.74 | PRKCI (0.45) | HPGDALDH1A1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL1419488 | 0.73 | MEN1 (0.37) | HPGDALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL21983719 | 0.73 | KMT2A (0.40) | HPGDALDH1A1SMN1; SMN2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | claimed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |