SCHEMBL473953

SCHEMBL473953

CCOC(=O)c1cncc([N+](=O)[O-])c1OCC(=O)OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.46
LMNA P02545 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
HPGD P15428 2/20 0.44
GALR2 O43603 1/20 0.44
MITF O75030 1/20 0.44
POLB P06746 1/20 0.44
HSP90AA1 P07900 1/20 0.44
XBP1 P17861 1/20 0.44
CCR6 P51684 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
GAA P10253 1/20 0.41
MAPT P10636 8/20 0.39
RAB9A P51151 4/20 0.39
NPC1 O15118 3/20 0.39
NFKB1 P19838 1/20 0.39
MAPK1 P28482 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
PDGFRB P09619 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1894132 0.76 ALDH1A1 (0.50) ALDH1A1LMNASMN1; SMN2HPGDGALR2
SCHEMBL2818590 0.74 LMNA (0.52) ALDH1A1LMNASMN1; SMN2HPGDGALR2
SCHEMBL1245682 0.74 ALDH1A1 (0.48) ALDH1A1LMNASMN1; SMN2HPGDGALR2
SCHEMBL26120722 0.73 ALDH1A1 (0.49) ALDH1A1LMNASMN1; SMN2HPGDGALR2
SCHEMBL4289394 0.73 LMNA (0.48) ALDH1A1LMNASMN1; SMN2HPGDGALR2
SCHEMBL4070785 0.72 ALDH1A1 (0.52) ALDH1A1LMNASMN1; SMN2HPGDGALR2
SCHEMBL7288738 0.71 GAA (0.45) ALDH1A1LMNASMN1; SMN2HPGDGALR2
SCHEMBL1245984 0.70 ALDH1A1 (0.46) ALDH1A1LMNASMN1; SMN2HPGDGALR2
SCHEMBL21824314 0.69 RAB9A (0.50) ALDH1A1LMNASMN1; SMN2POLBGAA
SCHEMBL25342867 0.69 PTGS2 (0.39) ALDH1A1LMNAPOLBMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2411365-A1 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS F. Hoffmann-La Roche AG (CH) 2012-02-01 EP disclosed
WO-2010108903-A1 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2010-09-30 WO disclosed