Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737726 | 0.81 | RAB9A (0.54) | RAB9APOLBNPC1ATMBCHE | |
| SCHEMBL8781612 | 0.81 | HPGD (0.53) | POLBMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL3069128 | 0.79 | RAB9A (0.71) | RAB9APOLBNPC1ATMBCHE | |
| SCHEMBL27410610 | 0.78 | HTT (0.40) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL7080560 | 0.78 | NAMPT (0.64) | RAB9APOLBNPC1ATMPTPN1 | |
| SCHEMBL4838149 | 0.77 | NOTUM (0.49) | NPC1TDP1ALDH1A1MAPTKDM4E | |
| SCHEMBL12719411 | 0.76 | ALDH1A1 (0.42) | POLBNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL6831588 | 0.74 | PTPRB (0.46) | PTPN1 | |
| SCHEMBL3894800 | 0.73 | TSHR (0.42) | RAB9ANPC1ALDH1A1MAPTKDM4E | |
| SCHEMBL3349318 | 0.72 | MLYCD (0.41) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086462-A2 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2008-07-17 | — | — | WO | disclosed |