Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29952924 | 1.00 | MAPK1 (0.51) | MAPK1TSHRMAOBALOX15KMT2A | |
| SCHEMBL19763606 | 0.90 | MAPK1 (0.46) | MAPK1TSHRMAOBALOX15KMT2A | |
| SCHEMBL6516041 | 0.89 | MAOB (0.51) | MAPK1TSHRMAOBALOX15KMT2A | |
| SCHEMBL235046 | 0.84 | TSHR (0.60) | MAPK1TSHRMAOBALOX15KMT2A | |
| SCHEMBL11225504 | 0.83 | CYP4F2 (0.67) | MAPK1TSHRALOX15KMT2AKDM4E | |
| SCHEMBL549144 | 0.83 | MAPK1 (0.54) | MAPK1TSHRMAOBALOX15KMT2A | |
| SCHEMBL29958024 | 0.82 | TSHR (0.54) | MAPK1TSHRKMT2AMEN1KDM4E | |
| SCHEMBL19893894 | 0.82 | TSHR (0.54) | MAPK1TSHRKMT2AMEN1KDM4E | |
| SCHEMBL27711843 | 0.81 | MAPK1 (0.47) | MAPK1TSHRMAOBALOX15KMT2A | |
| SCHEMBL19971601 | 0.81 | MAPK1 (0.52) | MAPK1TSHRMAOBALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11672791-B2 | Tyrosine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-11672791-B2 | Tyrosine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20230012676-A1 | TYROSINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-01-19 | — | — | US | disclosed |
| EP-3481826-B1 | TYROSINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2021-11-03 | — | — | EP | disclosed |
| US-11110082-B2 | Tyrosine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2021-09-07 | — | — | US | disclosed |
| US-20200078348-A1 | TYROSINE KINASE INHIBITORS | MIDCAP FINANCIAL TRUST | 2020-03-12 | — | — | US | disclosed |
| US-10434096-B2 | Tyrosine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2019-10-08 | — | — | US | disclosed |
| EP-3481826-A1 | TYROSINE KINASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2019-05-15 | — | — | EP | disclosed |
| US-20190099411-A1 | TYROSINE KINASE INHIBITORS | MIDCAP FINANCIAL TRUST | 2019-04-04 | — | — | US | disclosed |
| US-10130623-B2 | Tyrosine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2018-11-20 | — | — | US | disclosed |
| US-7795247-B2 | Tetracyclic indole derivatives as antiviral agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-09-14 | — | — | US | disclosed |
| WO-2010051237-A1 | 2,5-DISUBSTITUTED PHENYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-05-06 | — | — | WO | disclosed |
| WO-2010051237-A1 | 2,5-DISUBSTITUTED PHENYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-05-06 | — | — | WO | disclosed |
| US-20090298871-A1 | SULFONYL-PHENYL-2H-[1,2,4]OXADIAZOL-5-ONE DERIVATIVES , PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2009-12-03 | — | — | US | disclosed |
| EP-2102198-A1 | SULFONYL-PHENYL-2H-[1,2,4]OXODIAZOL-5-ONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2009-09-23 | — | — | EP | disclosed |
| WO-2009108670-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK SERONO S.A. (CH) | 2009-09-03 | — | — | WO | disclosed |
| WO-2008071311-A1 | SULFONYL-PHENYL-2H-[1,2,4]OXODIAZOL-5-ONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2008-06-19 | — | — | WO | disclosed |
| EP-1807403-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-07-18 | — | — | EP | disclosed |
| US-20060100262-A1 | Tetracyclic indole derivatives as antiviral agents | ISTITUTO DI RICHERCHEDI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IRMB) (IT) | 2006-05-11 | — | — | US | disclosed |
| WO-2006046030-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10130623-B2 | Tyrosine kinase inhibitors | TYRO3, AXL, RET | MAPK1 327/4885TSHR 295/4885MAOB 429/4885 |
| US-20190099411-A1 | TYROSINE KINASE INHIBITORS | TYRO3, AXL, RET | MAPK1 327/4885TSHR 295/4885MAOB 429/4885 |
| US-20060100262-A1 | Tetracyclic indole derivatives as antiviral agents | IDO1, ZC3HAV1, IDO2 | MAPK1 3736/4885TSHR 246/4885MAOB 259/4885 |
| US-11110082-B2 | Tyrosine kinase inhibitors | TYRO3, AXL, RET | MAPK1 327/4885TSHR 295/4885MAOB 429/4885 |
| US-20090298871-A1 | SULFONYL-PHENYL-2H-[1,2,4]OXADIAZOL-5-ONE DERIVATIVES , PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | PPARD, PPARG, PPARA | MAPK1 737/4885TSHR 269/4885MAOB 2786/4885 |
| US-20230012676-A1 | TYROSINE KINASE INHIBITORS | TYRO3, AXL, RET | MAPK1 327/4885TSHR 295/4885MAOB 429/4885 |
| US-10434096-B2 | Tyrosine kinase inhibitors | TYRO3, AXL, RET | MAPK1 327/4885TSHR 295/4885MAOB 429/4885 |
| US-11672791-B2 | Tyrosine kinase inhibitors | TYRO3, AXL, RET | MAPK1 327/4885TSHR 295/4885MAOB 429/4885 |
| US-20200078348-A1 | TYROSINE KINASE INHIBITORS | TYRO3, AXL, RET | MAPK1 327/4885TSHR 295/4885MAOB 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.